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Fig. 7 | Cancer Cell International

Fig. 7

From: MicroRNA-665 facilitates cell proliferation and represses apoptosis through modulating Wnt5a/β-Catenin and Caspase-3 signaling pathways by targeting TRIM8 in LUSC

Fig. 7

TRIM8 overexpression restrains LUSC tumor growth in vivo. a Morphology of excised tumors from nude mice were observed 28 days after being injected with LV-TRIM8-infected or LV-Ctrl-infected NCI-H226 cells. b Growth curves of tumor volume were generated every 3 days for 21 days. c Tumor weights were measured at day 28 after the injection. d TRIM8 mRNA expression in transplantation tumor was examined by qRT-PCR. e TRIM8 modulated the protein expressions of Wnt5a, β-Catenin, c-Myc, Cyclin D1 and active Caspase-3 in vivo. f Proposed model for the effects of TRIM8 on LUSC progression. miR-665 promotes human LUSC cell proliferation and suppresses apoptosis through regulation of the Wnt5a/β-Catenin and Caspase-3 signaling pathways by targeting TRIM8. n = 3, *p < 0.01, **p < 0.001

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Cancer Cell International

ISSN: 1475-2867

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