Table 3 KEGG signaling pathways centered on FGF1
Term description | Counts | Background gene counts | FDR | Matching proteins in the network |
|---|---|---|---|---|
Ras signaling pathway | 19 | 228 | 4.33e−27 | FGF4, FGF20, FGF23, PLCG1, FGF2, FGF10, FGF7, NTRK2, FGFR4, FGF19, FGF8, FGF3, FGFR3, FGF9, GRB2, FGFR1, FGFR2, NTRK1, FGF1 |
MAPK signaling pathway | 18 | 293 | 1.85e−23 | FGF4, FGF20, FGF23, FGF2, FGF10, FGF7, NTRK2, FGFR4, FGF19, FGF8, FGF3, FGFR3, FGF9, GRB2, FGFR1, FGFR2, NTRK1, FGF1 |
PI3K-AKT signaling pathway | 18 | 348 | 2.42e−22 | FGF4, FGF20, FGF23, FGF2, FGF10, FGF7, NTRK2, FGFR4, FGF19, FGF8, FGF3, FGFR3, FGF9, GRB2, FGFR1, FGFR2, NTRK1, FGF1 |
Regulation of actin cytoskeleton | 15 | 205 | 1.56e−20 | FGF4, FGF20, FGF23, FGF2, FGF10, FGF7, FGFR4, FGF19, FGF8, FGF3, FGFR3, FGF9, FGFR1, FGFR2, FGF1 |
Signaling pathways regulating pluripotency of stem cells | 6 | 138 | 7.10e−7 | FGF2, FGFR4, FGFR3, GRB2, FGFR1, FGFR2 |
EGFR tyrosine kinase inhibitor resistance | 5 | 78 | 1.36e−6 | PLCG1, FGF2, FGFR3, GRB2, FGFR2 |
Insulin secretion | 3 | 84 | 0.0019 | STX1A, SNAP25, VAMP2 |