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Fig. 1 | Cancer Cell International

Fig. 1

From: Cyproheptadine, an epigenetic modifier, exhibits anti-tumor activity by reversing the epigenetic silencing of IRF6 in urothelial carcinoma

Fig. 1

IRF6 is upregulated in UC cells treated with CPH. a Bar chart showing genes that are up-regulated after BFTC905 UC cells treated with 55 µM CPH for 24 h as identified by RNA-Seq. b Gene Ontology categories showing upregulated genes in BFTC cells after treatment with CPH, as compared with DMSO control. c Relative expression level of IRF6 in SV-HUC1 and various UC cell lines, relative to GAPDH as an internal control. ***(p < 0.001, comparing SV-HUC1 to each cell line). d Various UC cells treated with 55 µM CPH for 24, 48 and 72 hr were examined for expression by qRT-PCR. Relative expression levels were compared with cells treated with DMSO as control. Significant differences from the control were indicated by *(p < 0.05), **(p < 0.01), and ***(p < 0.001), as determined by t-test

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