Fig. 3

a SLC1A5 transports glutamine into cells and is converted to glutamate by glutaminase, which participates in the synthesis of GSH together with intracellular Cys. SLC7A11 exchanges extracellular cystine and intracellular glutamate, and c-myc participates in the positive regulation of SLC1A5 and SLC7A11. Glutamate is converted into α-KG by L-glutamate dehydrogenase or aminotransferases, which participates in the TCA cycle. α-KG participates in the reductive carboxylation process to produce citrate, which used for the synthesis of acetyl-CoA and lipids, aspartate produced by oxaloacetic acid transamination is a necessary substance for nucleotide synthesis. b LncRNAs which are involved in regulating amino acid metabolism