A nomogram for predicting survival of head and neck mucosal melanoma

Table 2 Univariate Cox regression analysis of OS and DFS in the primary cohort

Variable	OS		DFS
Variable	HR (95% CI)	P	HR (95% CI)	P
Gender
Male	Reference		Reference
Female	0.964 (0.717–1.297)	0.811	1.051 (0.766–1.442)	0.759
Age (years old)
< 60	Reference		Reference
≥ 60	1.246 (0.934–1.660)	0.134	1.203 (0.881–1.644)	0.245
Smoking
No	Reference		Reference
Yes	1.020 (0.747–1.395)	0.899	0.787 (0.591–1.049)	0.102
Primary site
Others	Reference		Reference
Nasal cavity	2.127 (1.256–3.603)	0.005^**	1.510 (0.996–2.288)	0.052
Paranasal sinus	6.113 (3.101–12.052)	< 0.001^***	3.066 (1.733–5.425)	< 0.001^***
Oral cavity	2.586 (1.465–4.564)	0.001^**	2.217 (1.413–3.479)	0.001^**
8th T stage
T3	Reference		Reference
T4a	2.801 (1.968–3.989)	< 0.001^***	2.150(1.596–2.896)	< 0.001^***
T4b	11.025(7.301–16.647)	< 0.001^***	6.179 (4.227–9.034)	< 0.001^***
8th N stage
N0	Reference		Reference
N1	1.542 (1.113–2.237)	0.009^**	1.637 (1.223–2.191)	0.001^**
Surgery
No	Reference		Reference
Yes	0.707 (0.409–1.220)	0.212	0.612 (0.386–0.969)	0.036^*
Radiotherapy
No	Reference		Reference
Yes	1.178 (0.879–1.580)	0.273	1.070 (0.828–1.383)	0.603
Chemotherapy
No	Reference		Reference
Yes	0.863 (0.647–1.151)	0.317	1.022 (0.792–1.318)	0.869
Immunologic/targeted therapy
No	Reference		Reference
Yes	0.694 (0.495–0.974)	0.035^*	0.873 (0.657–1.159)	0.348

Cox proportional hazard model was used to conduct Cox regression analysis. * p value < 0.05; ** p value < 0.01; ** p value < 0.001

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