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Fig. 1 | Cancer Cell International

Fig. 1

From: ESR1 as a recurrence-related gene in intrahepatic cholangiocarcinoma: a weighted gene coexpression network analysis

Fig. 1

Construction of the weighted gene coexpression network. a Clustering dendrogram of 29 tumor samples and heatmaps of clinical traits. The color intensity in the heatmaps was proportional to increased days to death, improved overall survival, a higher pathological stage, higher T stage, or higher N stage. White indicates no death, no family history, or no recurrence, and red denotes a deceased patient who had tumor-related death, family history, or tumor recurrence. Gray represents values that are unavailable in the TCGA database; b Analysis of the scale-free fit index for various soft-thresholding powers (b); b = 8 was selected for subsequent analysis. c Clustering dendrogram of DEGs with dissimilarity based on topological overlap, together with assigned module colors. d Visualization of the gene network by using a heatmap. The heatmap depicts the TOM among all genes in the analysis. A light color represents low overlap, and a progressively darkening red color represents increased overlap. The gene dendrogram and module assignment are also presented along the left side and the top. e Module-trait heatmap. Each row corresponds to an ME, and each column corresponds to a clinical trait. Each cell contains the corresponding correlation and P-value; NS means P > 0.05

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