ESR1 as a recurrence-related gene in intrahepatic cholangiocarcinoma: a weighted gene coexpression network analysis

Table-2 Univariable Cox regression for DFS in two cohorts

Characteristics	P-value	HR	Low 95% CI	High 95% CI
TCGA cohort
Age, > 50 vs. ≤ 50	0.785	0.805	0.170	3.810
Gender, Male vs. Female	0.279	0.514	0.154	1.713
Family history, Yes vs. No	0.109	0.384	0.119	1.240
Hepatitis virus infection, Yes vs. No	0.535	0.043	0.00	874.9
CA19-9 level	0.521	1.002	0.997	1.006
Tumor TNM stage	0.376	1.832	0.480	7.001
MVI, Yes vs. No	0.964	0.953	0.121	7.496
ESR1 expression	0.031	0.594	0.370	0.953
Validation cohort
Age, > 50 vs. ≤ 50	0.700	1.253	0.398	3.941
Gender, Male vs. Female	0.600	0.771	0.293	2.034
Family history, Yes vs. No	–	–	–	–
Hepatitis virus infection, Yes vs. No	0.837	0.904	0.346	2.363
CA19-9 level	0.066	1.002	1.000	1.003
Tumor TNM stage	0.619	0.835	0.409	1.702
MVI, Yes vs. No	0.003	5.527	1.790	17.066
ESR1 expression	0.025	0.804	0.665	0.972

The bold data mean that the characteristics are significant prognostic factors for DFS (P < 0.05)

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