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Table-2 Univariable Cox regression for DFS in two cohorts

From: ESR1 as a recurrence-related gene in intrahepatic cholangiocarcinoma: a weighted gene coexpression network analysis

Characteristics P-value HR Low 95% CI High 95% CI
TCGA cohort
 Age, > 50 vs. ≤ 50 0.785 0.805 0.170 3.810
 Gender, Male vs. Female 0.279 0.514 0.154 1.713
 Family history, Yes vs. No 0.109 0.384 0.119 1.240
 Hepatitis virus infection, Yes vs. No 0.535 0.043 0.00 874.9
 CA19-9 level 0.521 1.002 0.997 1.006
 Tumor TNM stage 0.376 1.832 0.480 7.001
 MVI, Yes vs. No 0.964 0.953 0.121 7.496
 ESR1 expression 0.031 0.594 0.370 0.953
Validation cohort
 Age, > 50 vs. ≤ 50 0.700 1.253 0.398 3.941
 Gender, Male vs. Female 0.600 0.771 0.293 2.034
 Family history, Yes vs. No
 Hepatitis virus infection, Yes vs. No 0.837 0.904 0.346 2.363
 CA19-9 level 0.066 1.002 1.000 1.003
 Tumor TNM stage 0.619 0.835 0.409 1.702
 MVI, Yes vs. No 0.003 5.527 1.790 17.066
 ESR1 expression 0.025 0.804 0.665 0.972
  1. The bold data mean that the characteristics are significant prognostic factors for DFS (P < 0.05)