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Fig. 7 | Cancer Cell International

Fig. 7

From: Identification of an immune-related signature indicating the dedifferentiation of thyroid cells

Fig. 7

Exploring the role of the risk score in immune-related signatures. a, b Plots indicating the correlations between the risk score and the immune checkpoint molecules CD274 (PDL1), CTLA4, IDO1, and HAVCR2 (TIM3) in the combined GEO cohort (a) and TCGA cohort (b) (Pearson test). c Comparison of the infiltration of immune cells between the low risk score and high risk score samples in the combined GEO cohort (Wilcoxon test). d The association between the risk score and the infiltration of immune cells in the combined GEO cohort (Pearson test). e Response to anti-PD-L1 immunotherapy in the low- and high-risk-score groups in the IMvigor210 cohort (chi-square test, p = 0.003) (CR complete response, PR partial response, SD stable disease, PD progressive disease). f Distribution of the risk score among patients with different anti-PD-L1 treatment responses in the IMvigor210 cohort (Wilcoxon test). g Response to anti-CTLA4 immunotherapy in the low- and high-risk-score groups in the GSE63557 cohort (two-sided Fisher’s exact test, p = 0.18). h Distribution of the risk score among mice with different anti-CTLA4 treatment responses in the GSE63557 cohort (Wilcoxon test)

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