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Table 1 Exosomal microRNA detected in HCC and clinical relevance

From: Exosomal microRNAs in hepatocellular carcinoma

Exosomal MicroRNA Parental cells Recipient cells Expression level in HCC Target Potential Mechanism References
miR-210 HCC cells Endothelial cells Upregulated SMAD4, STAT6 Promote tumor angiogenesis [42]
miR-744 HepG2 cells   Downregulated PAX2 Inhibit HepG2 cell proliferation and promotes the chemosensitivity of HepG2 cells to sorafenib [112]
miR-21, miR-10b HCC cells   Upregulated in Acidic Microenvironment   Promote cancer cell proliferation and metastasis [94]
miR-1247-3p High-metastatic HCC cells Fibroblasts   B4GALT3 Activate β1-integrin-NF-κB signaling in fibroblasts and promote cancer progression [91]
miR-451a    Downregulated LPIN1 Promote apoptosis in HCC and endothelial cells [78]
miR-23a-3p ER-stressed HCC cells Macrophages   PTEN Regulate PD-L1 expression through the PTEN-PI3K/AKT pathway and help tumor cells escape from antitumor immunity [59]
miR-32-5p Multidrug-resistant cell (Bel/5-FU) Sensitive cell (Bel7402) Upregulated PTEN Activate the PI3K/Akt pathway to further induce multidrug resistance by modulating angiogenesis and EMT [58]
miR-92b HCC cells Natural killer (NK) cells Upregulated   Promote the downregulation of CD69 and NK cell-mediated cytotoxicity [116]
miR-320a Stromal cells HCC cells Downregulated PBX3 Inhibit tumor progression by suppressing the activation of the MAPK pathway [68]
miR-638 HCC cells HCC cells, human umbilical vein endothelial cells (HUVECs) Downregulated SP1 Repress HCC cell proliferation by decreasing viability and colony formation, and decreased abilities of migration and invasion. [77]
miR-200b-3p HCC cells Endothelial cells Downregulated   Suppress endothelial ERG expression [103]