Fig. 2

a Venn diagram of the proteins extracted from cell lysates of HMPOS-S, HMPOS-2.5R and HMPOS-10R show that majority of proteins are shared between the three cell lines. HMPOS-S express 60 unique proteins while HMPOS-2.5R and HMPOS-10R express 8 and 145 unique proteins respectively. b HMPOS-2.5R cell lysates miRNA associated proteins. Columns represent odds ratio values; the red colored columns correlate to P value of < 0.05. c HMPOS-2.5R cell lysates pathway analysis of expressed proteins (columns in red have P value of < 0.05). The glutathione biosynthesis and recycling and conjugation pathways exhibit a significant P value which is in line with their resistance to carboplatin. d HMPOS-10R cell lysates miRNA. e HMPOS-10R cell lysates pathway analysis exhibit significance of pathways associated with platinum agents drug resistance such as gamma-glutamyltrasferase synthesis. f Immunoblot assay for HMPOS-S, HMPOS-2.5R and HMPOS-10R cell lysates, exhibit an increased concentration of de-phosphorylated β-catenin with increased cellular resistance to carboplatin