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Fig. 3 | Cancer Cell International

Fig. 3

From: Exosomal proteomic signatures correlate with drug resistance and carboplatin treatment outcome in a spontaneous model of canine osteosarcoma

Fig. 3

a Venn diagram identify 411 shared proteins the exosomes extracted from HMPOS-S, HMPOS-2.5R, and HMPOS-10R, and 121, 71 and 49 unique proteins respectively. b HMPOS-2.5R exosomal miRNA associated proteins, the colored columns correlate to P value of < 0.05. c HMPOS-2.5R Exosomal proteins analysis revealed the upregulation of histone modification and nucleotide metabolism pathways which correlate with platinum agents drug resistance. d HMPOS-10R display exosomal miRNA related proteins (columns in red have P value of < 0.05). e HMPOS-10R exosomal protein analysis. f light scatter analysis of exosomes extracted from HMPOS-S cells supernatants exhibit nanoparticle size with a mean of 64.2 nm. g Light scatter analysis of exosomes extracted from HMPOS-2.5R cells supernatants with a mean value of 87 nm. h light scatter analysis of exosomes extracted from HMPOS-10R cells supernatants exhibit a mean value of 67.4 nm

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