Fig. 4

a Propidium iodide histogram of sensitive and resistant HMPOS cell lines demonstrate the accumulation of HMPOS-10R at the G2/M phase. b Cell Phase of sensitive and resistant cell lines exhibit a significant decrease of the HMPOS 10 R cells in the G0/G1 phase and their accumulation at the G2/M phase (n = 3, [*] = P < 0.05, [***] = P < 0.001). c Exosomes extracted from sensitive and resistant cells lines coincubation with HMPOS S cells show no changes in cell phase (n = 3). d HMPOS-S Co-incubation with Exosomes of sensitive and resistant cell lines demonstrate an increased proliferation independent of the exosome’s origin (n = 3). e HMPOS-S Co-incubation with Exosomes of sensitive and resistant cell lines and with carboplatin demonstrating increased resistance of these cells to high concentration of carboplatin following coincubation with exosomes from HMPOS-2.5R (n = 3, [*] = P < 0.05). f Immunoblot assay for HMPOS-S cells demonstrate the decrease of phosphorylated β-catenin and increased of dephosphorylation following coincubation with exosomes extracted from supernatants of carboplatin resistant cell lines