Fig. 5

a Light scatter analysis of exosomes extracted from the serum of a dog from the “good doer” cohort (dog #2), and dog from the “poor doer” cohort (dog #6) demonstrate the extracted exosome size and concentration. b Each mark represents a serum exosome sample, color-coded by outcome. Horizontal axis represents the net prediction score contribution from serum exosome protein features that are negatively correlated with good outcome, for that sample. Vertical axis represents the net prediction score contribution from serum exosome protein features that are positively correlated with good outcome, for that sample. Line denotes the decision boundary for predicting outcome. c Each mark represents a serum exosome sample, grouped by outcome. Vertical axis represents the net prognosis prediction score (lower score means better prognosis; higher score means worse prognosis). d Each cell in the heatmap represents a combination of serum exosome sample (row) and protein identified by UniProt accession (column). Heatmap color indicates relative log2 expression of the indicated protein in the specified sample relative to the column average (see Methods). Heatmap of the protein expression demonstrate distinct patterns between the cohort of good doers (Dog #1–5) and poor doers (Dog #6–10)