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Table 1 Selected over expressed proteins in cell lysates of carboplatin resistant cell lines

From: Exosomal proteomic signatures correlate with drug resistance and carboplatin treatment outcome in a spontaneous model of canine osteosarcoma

Protein name 2.5 R 10 R Biological function
Gamma-glutamylcyclotransferase   Glutathione Metabolism, EMT regulation via PI3K/AKT/mTOR
Heat shock Protein 27   Anti-apoptotic
S100A7 EMT, migration, invasion
Cyclin-dependent kinase 6   Cell Cycle Progression
histone deacetylase   Chromatin Remodeling
14-3-3 protein sigma   Cell Signaling
Cyclin-dependent kinase 2   Cell Cycle Progression
Insulin-like growth factor 2 mRNA-binding protein 3   Stabilizing IGF-2 mRNA
β-catenin Cell Signaling
Transgelin   Stemness, invasion
Follistatin-related protein 1 Marker of EMT, invasion
Stathmin   Cell cycle arrest via microtubule depolymerization
14-3-3 protein theta   Cell Signaling
Insulin-like growth factor 2 mRNA-binding protein 2   Stabilizing IGF-2 mRNA
Sialidase Neu2   Invasion, metastasis, differentiation state
Glutamine synthetase   Glutamine metabolism
Alpha-2-macroglobulin Protease inhibitor, stemness, platinum inactivation
Adenosylhomocysteinase   Alteration of DNA methylation via Adenosylhomocysteine level control
UV excision repair protein RAD23 homolog A   DNA repair
N-Cadherin Marker of EMT
Secreted frizzled-related protein 2   Wnt signaling, tissue regeneration
Gamma-enolase   Increased glycolysis