Table 1 Selected over expressed proteins in cell lysates of carboplatin resistant cell lines
Protein name | 2.5 R | 10 R | Biological function |
|---|---|---|---|
Gamma-glutamylcyclotransferase | ✓ | Glutathione Metabolism, EMT regulation via PI3K/AKT/mTOR | |
Heat shock Protein 27 | ✓ | Anti-apoptotic | |
S100A7 | ✓ | ✓ | EMT, migration, invasion |
Cyclin-dependent kinase 6 | ✓ | Cell Cycle Progression | |
histone deacetylase | ✓ | Chromatin Remodeling | |
14-3-3 protein sigma | ✓ | Cell Signaling | |
Cyclin-dependent kinase 2 | ✓ | Cell Cycle Progression | |
Insulin-like growth factor 2 mRNA-binding protein 3 | ✓ | Stabilizing IGF-2 mRNA | |
β-catenin | ✓ | ✓ | Cell Signaling |
Transgelin | ✓ | Stemness, invasion | |
Follistatin-related protein 1 | ✓ | ✓ | Marker of EMT, invasion |
Stathmin | ✓ | Cell cycle arrest via microtubule depolymerization | |
14-3-3 protein theta | ✓ | Cell Signaling | |
Insulin-like growth factor 2 mRNA-binding protein 2 | ✓ | Stabilizing IGF-2 mRNA | |
Sialidase Neu2 | ✓ | Invasion, metastasis, differentiation state | |
Glutamine synthetase | ✓ | Glutamine metabolism | |
Alpha-2-macroglobulin | ✓ | ✓ | Protease inhibitor, stemness, platinum inactivation |
Adenosylhomocysteinase | ✓ | Alteration of DNA methylation via Adenosylhomocysteine level control | |
UV excision repair protein RAD23 homolog A | ✓ | DNA repair | |
N-Cadherin | ✓ | ✓ | Marker of EMT |
Secreted frizzled-related protein 2 | ✓ | Wnt signaling, tissue regeneration | |
Gamma-enolase | ✓ | Increased glycolysis |