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Table 2 Selected Overexpressed proteins in exosomal cargo of carboplatin resistant cells

From: Exosomal proteomic signatures correlate with drug resistance and carboplatin treatment outcome in a spontaneous model of canine osteosarcoma

Protein Name 2.5 R 10 R Biological Function
Metallothionein-1G Carboplatin Inactivation
Heat shock Protein 105 kDa   β-catenin dephosphorylation via protein phosphatase 2A recruitment
S100A10 Conditioning distant sites for metastasis via exosomes
LDLR chaperone MESD   Wnt Signaling
Integrin beta Conditioning distant sites for metastasis via exosomes
14–3-3 protein eta   Cell Signaling
ILF3   Promotes Survivin expression
Insulin-like growth factor 2 mRNA-binding protein 1   Stabilizing IGF-2 mRNA
β-catenin Cell Signaling
Transgelin Stemness, invasion
Heat shock Protein 27   Anti-apoptotic
Follistatin-related protein 1 Invasion
Stathmin Cell cycle arrest via microtubule depolymerization
Heterogeneous nuclear ribonucleoprotein Q miRNA loading into exosomes
Histone H1.3 Binding of cis-platinated DNA
14–3-3 protein theta   Cell Signaling
Gamma-enolase   Glycolysis
WD repeat and HMG-box DNA-binding protein 1   DNA Damage Response
SWI/SNF complex subunit SMARCC2   Chromatin Remodeling
Serine hydroxymethyltransferase, mitochondrial   Chromatin Remodeling
Histone deacetylase 2   Chromatin Remodeling
Hypoxanthine–guanine phosphoribosyltransferase   Nucleotide Metabolism
ribose-phosphate pyrophosphokinase 1   Nucleotide Metabolism