Table 2 Selected Overexpressed proteins in exosomal cargo of carboplatin resistant cells
Protein Name | 2.5 R | 10 R | Biological Function |
|---|---|---|---|
Metallothionein-1G | ✓ | ✓ | Carboplatin Inactivation |
Heat shock Protein 105 kDa | ✓ | β-catenin dephosphorylation via protein phosphatase 2A recruitment | |
S100A10 | ✓ | ✓ | Conditioning distant sites for metastasis via exosomes |
LDLR chaperone MESD | ✓ | Wnt Signaling | |
Integrin beta | ✓ | ✓ | Conditioning distant sites for metastasis via exosomes |
14–3-3 protein eta | ✓ | Cell Signaling | |
ILF3 | ✓ | Promotes Survivin expression | |
Insulin-like growth factor 2 mRNA-binding protein 1 | ✓ | Stabilizing IGF-2 mRNA | |
β-catenin | ✓ | ✓ | Cell Signaling |
Transgelin | ✓ | ✓ | Stemness, invasion |
Heat shock Protein 27 | ✓ | Anti-apoptotic | |
Follistatin-related protein 1 | ✓ | ✓ | Invasion |
Stathmin | ✓ | ✓ | Cell cycle arrest via microtubule depolymerization |
Heterogeneous nuclear ribonucleoprotein Q | ✓ | ✓ | miRNA loading into exosomes |
Histone H1.3 | ✓ | ✓ | Binding of cis-platinated DNA |
14–3-3 protein theta | ✓ | Cell Signaling | |
Gamma-enolase | ✓ | Glycolysis | |
WD repeat and HMG-box DNA-binding protein 1 | ✓ | DNA Damage Response | |
SWI/SNF complex subunit SMARCC2 | ✓ | Chromatin Remodeling | |
Serine hydroxymethyltransferase, mitochondrial | ✓ | Chromatin Remodeling | |
Histone deacetylase 2 | ✓ | Chromatin Remodeling | |
Hypoxanthine–guanine phosphoribosyltransferase | ✓ | Nucleotide Metabolism | |
ribose-phosphate pyrophosphokinase 1 | ✓ | Nucleotide Metabolism |