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Fig. 2 | Cancer Cell International

Fig. 2

From: Small molecule inhibitors against PD-1/PD-L1 immune checkpoints and current methodologies for their development: a review

Fig. 2

The structure of PD-L1 (4ZQK) and three main hot spots between PD-1 and PD-L1. a The structures of PD-L1 and PD-1. Amino acid residues in the main hot spots are labeled as orange color. b Three main hot spots are exhibited. The first hotspot includes lTyr56, lGlu58, lArg113, lMet115, and lTyr123. The second hotspot includes lMet115, lAla121, and lTyr123. The third hotspot is an extended groove formed by the main chain and the side chains spanning residues lAsp122 to lArg125, and is flanked by the side chain of lAsp26

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Cancer Cell International

ISSN: 1475-2867

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