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Table 1 Distribution of SCUBE3 expression with clinicopathologic characteristics of breast cancer (N = 137)

From: SCUBE3 serves as an independent poor prognostic factor in breast cancer

Variable   SCUBE3 expression p-value
Total Low High  
Number 137 106 (77.4%) 31 (22.6%)  
Age, years 55.9 ± 11.7 55.9 ± 11.8 55.7 ± 11.7 0.952
Histologic grade     0.514
 2 95 (69.3%) 81 (85.3%) 14 (14.7%)  
 3 42 (30.7%) 25 (59.5%) 17 (40.5%)  
Histologic type     0.399
 Invasive ductal 114 (83.2%) 86 (75.4%) 28 (24.6%)  
 Other 23 (16.8%) 20 (87.0%) 3 (13.0%)  
Tumor size, cm     0.0798
  ≤ 2 55 (40.1%) 42 (76.4%) 13 (23.6%)  
  > 2 82 (59.9%) 64 (78.0%) 18 (22.0%)  
Lymph node metastasis     0.907
 Negative 72 (52.6%) 55 (76.4%) 17 (23.6%)  
 Positive 65 (47.4%) 51 (78.5%) 14 (21.5%)  
TMN stage     0.0725
 I 39 (28.5%) 30 (76.9%) 9 (23.1%)  
 II 52 (38.0%) 41 (78.8%) 11 (21.2%)  
 III 46 (33.6%) 35 (76.1%) 11 (23.9%)  
ER     0.018
 Negative 31 (23.1%) 19 (61.3%) 12 (38.7%)  
 Positive 103 (76.9%) 55 (53.4%) 48 (46.6%)  
 Missing 3 2 1  
PR     0.015
 Negative 24 (17.8%) 15 (62.5%) 9 (37.5%)  
 Positive 111 (82.2%) 60 (54.1%) 51 (45.9%)  
 Missing 2 1 1  
HER2     0.039
 Negative 109 (87.9%) 64 (58.7%) 45 (41.3%)  
 Positive 15 (12.1%) 9 (60.0%) 6 (40.0%)  
 Missing 13 11 2  
E-cadherin     0.020
 Negative 45 (38.1%) 30 (66.7%) 15 (33.3%)  
 Positive 73 (61.9%) 62 (84.9%) 11 (15.1%)  
 Missing
Subtypes
19 14 5 0.706
Luminal A 79 (62.2%) 35 (44.3%) 44 (55.7%)  
Luminal B 17 (13.4%) 9 (53.0%) 8 (47.1%)  
HER2 16 (12.6%) 6 (37.5%) 10 (62.5%)  
TNBC 25 (19.7%) 10 (40%) 15 (60.0%)  
Missing 10 3 7  
Recurrence     0.855
 Yes 38 (27.7%) 29 (76.3%) 9 (23.7%)  
 No 99 (72.3%) 77 (77.8%) 22 (22.2%)  
Survival state     0.032
 Survival 108 (78.8%) 89 (82.4%) 19 (17.6%)  
 Death 29 (21.2%) 12 (41.4%) 17 (58.6%)  
  1. ER estrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor; TMN stage was according to the seventh edition of the Guidelines for the American Journal of Critical Care. Variables are expressed as n (%) or the mean ± SD