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Table 2 Effects of death risk factors on breast cancer by univariate analysis (N = 137)

From: SCUBE3 serves as an independent poor prognostic factor in breast cancer

Variable

Total

HR (95% CI)

P-value

SCUBE3

   

 Low

106 (77.4%)

Reference

 

 High

31 (22.6%)

2.77 (1.32, 5.80)

0.0070

Age, years

55.89 ± 11.73

1.05 (1.02, 1.08)

0.0025

Histologic grade

   

 2

95 (69.3%)

Reference

 

 3

42 (30.7%)

2.14 (1.03, 4.44)

0.0422

Histologic type

   

 Invasive ductal

114 (83.2%)

Reference

 

 Other

23 (16.8%)

1.24(0.50, 3.03)

0.6445

Tumor size, cm

  

0.2435

  ≤ 2

55 (40.1%)

Reference

 

  > 2

82 (59.9%)

1.28 (0.56, 2.74)

0.5329

Lymph node metastasis

   

 Negative

72 (52.6%)

Reference

 

 Positive

65 (47.4%)

2.73 (1.24, 6.00)

0.0123

TMN stage

   

 I

39 (28.5%)

Reference

 

 II

52 (37.9%)

2.45 (0.66, 9.05)

0.1789

 III

46 (33.6%)

5.70 (1.67, 19.46)

0.0055

ER

   

 Negative

41 (30.6%)

Reference

 

 Positive

93 (69.4%)

0.32 (0.15, 0.67)

0.0023

 Missing

2

1

1

PR

   

 Negative

45 (33.1%)

Reference

 

 Positive

91 (66.9%)

0.73 (0.35, 1.51)

0.0395

 Missing

1

-

1

HER2

   

 Negative

100 (80.6%)

Reference

 

 Positive

24 (19.4%)

1.22 (0.49, 3.04)

0.6676

 Missing

13

11

2

E-cadherin

   

 Negative

45 (38.1%)

Reference

 

 Positive

73 (61.9%)

0.9 (0.43, 1.89)

0.7886

 Missing

19

14

5

TNBC

   

 No

108 (82.4%)

Reference

 

 Yes

23 (17.6%)

2.61 (1.17, 5.81)

0.0189

 Missing

6

4

2

  1. ER estrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor
  2. TMN stage was according to the seventh edition of the Guidelines for the American Journal of Critical Care. Variables are expressed as n (%)