From: SCUBE3 serves as an independent poor prognostic factor in breast cancer
Variable | Total | HR (95% CI) | P-value |
---|---|---|---|
SCUBE3 | Â | Â | Â |
 Low | 106 (77.4%) | Reference |  |
 High | 31 (22.6%) | 2.77 (1.32, 5.80) | 0.0070 |
Age, years | 55.89 ± 11.73 | 1.05 (1.02, 1.08) | 0.0025 |
Histologic grade | Â | Â | Â |
 2 | 95 (69.3%) | Reference |  |
 3 | 42 (30.7%) | 2.14 (1.03, 4.44) | 0.0422 |
Histologic type | Â | Â | Â |
 Invasive ductal | 114 (83.2%) | Reference |  |
 Other | 23 (16.8%) | 1.24(0.50, 3.03) | 0.6445 |
Tumor size, cm | Â | Â | 0.2435 |
  ≤ 2 | 55 (40.1%) | Reference |  |
  > 2 | 82 (59.9%) | 1.28 (0.56, 2.74) | 0.5329 |
Lymph node metastasis | Â | Â | Â |
 Negative | 72 (52.6%) | Reference |  |
 Positive | 65 (47.4%) | 2.73 (1.24, 6.00) | 0.0123 |
TMN stage | Â | Â | Â |
 I | 39 (28.5%) | Reference |  |
 II | 52 (37.9%) | 2.45 (0.66, 9.05) | 0.1789 |
 III | 46 (33.6%) | 5.70 (1.67, 19.46) | 0.0055 |
ER | Â | Â | Â |
 Negative | 41 (30.6%) | Reference |  |
 Positive | 93 (69.4%) | 0.32 (0.15, 0.67) | 0.0023 |
 Missing | 2 | 1 | 1 |
PR | Â | Â | Â |
 Negative | 45 (33.1%) | Reference |  |
 Positive | 91 (66.9%) | 0.73 (0.35, 1.51) | 0.0395 |
 Missing | 1 | - | 1 |
HER2 | Â | Â | Â |
 Negative | 100 (80.6%) | Reference |  |
 Positive | 24 (19.4%) | 1.22 (0.49, 3.04) | 0.6676 |
 Missing | 13 | 11 | 2 |
E-cadherin | Â | Â | Â |
 Negative | 45 (38.1%) | Reference |  |
 Positive | 73 (61.9%) | 0.9 (0.43, 1.89) | 0.7886 |
 Missing | 19 | 14 | 5 |
TNBC | Â | Â | Â |
 No | 108 (82.4%) | Reference |  |
 Yes | 23 (17.6%) | 2.61 (1.17, 5.81) | 0.0189 |
 Missing | 6 | 4 | 2 |