Skip to main content
Fig. 5 | Cancer Cell International

Fig. 5

From: Dual effects of targeting S100A11 on suppressing cellular metastatic properties and sensitizing drug response in gastric cancer

Fig. 5

Role of S100A11 in the cellular response to therapeutic drugs. Effects of the S100A11 knockdown on colony formation in response to cisplatin and 5-Fu were evaluated in the stable AGS (a) and HGC27 (b), respectively. The representative images of colony formation are shown at the bottom. The change of the apoptosis levels indicated by FACS-based cleaved PARP in the stable AGS (c) and HGC27 cells (d), respectively. Western blotting was used to quantify the change of P53, P21 and cleaved-PARP proteins in the AGS (e) and HGC27 cells (f), respectively. Caspase 3/7 assay was used to verify the apoptosis in response to cisplatin or 5-Fu in the stable AGS (g) and HGC27 cells (h), respectively

Back to article page