Fig. 1

Structure of the human RFX transcription factors 1–8 with conserved DNA binding domains. Isoforms of RFX4 and RFX8 lack a DNB (DNA binding domain). DNB, B, C, and DIM (Dimerization domain) are conserved among most RFX proteins. RFX1 transcription factor has proline- and glutamine-rich region (PQ), glutamine-rich region (Q), glycine-rich region (G), a highly acidic stretch (DE) near the C-terminal region at 920–936 aa (amino acids), and nuclear localization signals (NLS-1 near c-terminal and NLS-2 within DBD)