Fig.2

RFX1 expression and mutation analysis. a Boxplot graph illustrating the tissue-wide gene expression pattern of RFX1 across 70 paired tissues (GPL570) from micro-array database GENT2 (Access GENT2 free at http://gent2.appex.kr). Log2 fold changes of each cancer tissue compared to its normal tissues are plotted—Red (cancer samples) versus blue (normal samples). b This figure depicts the percentage of tumor samples with RFX1 missense mutations from 15 types of cancers on the TGCA database (https://www.phosphosite.org/proteinAction.action?id=5813) [55]. c The figure shows RFX1 mutations and PTM sites, visualized using cBioPortal, an open-source, public platform from a collective of 10,953 patients/10,967 samples comprising 46 different studies present in the TCGA Pan-Cancer Atlas Studies. The Lollipop plot illustrates a total of 111 missense mutations (green) and 21 truncating (black) mutations in 979 amino acids long RFX1 protein [150, 151]