Table 2 RFX1 co-activators and co-repressor
RFX1 interacting protein | Co-activator | Co-repressor | Function |
|---|---|---|---|
MIBP1 | Â |
| Nuclear localization of RFX1; transcriptional repression of c-Myc in RA induced HL60 cell line [19] |
| Â | Upregulation of MHC class II gene transcription [11, 12] transactivation of HBV enhancer activity [36] | |
AP4 |
| Â | Increase SHP1 transcription in MCF-7 cell lines to reduce cell proliferation [81] |
NF1 | Â |
| NF1/RFX1 binds to P sequence element of chorionic somatomammotropins gene promoter and represses its activity [162] |
ADD1 | Â |
| Co-repressor of RFX1 in the COS-7 kidney fibroblast cell line [163] |
p107 | Â |
| p107/ RFX1 utilized the RFX1 binding site and repressed PCNA [157] |
CREB |
| Â | CCAR2 stabilizes RFX1/CREB complex which transcriptionally regulates cell cycle genes involved in cancer progression in HO1N1 SCC cell line [144] |
PP1c | Â |
| Involved in RFX1 autorepression [87] |
HDAC | Â |
| RFX1 recruits HDAC and represses COL1A2 promoter activity [64] |
mSin3A | Â |
| RFX1 recruits mSin3A and represses COL1A2 promoter activity [64] |
