Table 2 RFX1 co-activators and co-repressor
| RFX1 interacting protein | Co-activator | Co-repressor | Function |
|---|---|---|---|
| MIBP1 |
| Nuclear localization of RFX1; transcriptional repression of c-Myc in RA induced HL60 cell line [19] | |
|
|
Upregulation of MHC class II gene transcription [11, 12] transactivation of HBV enhancer activity [36] | ||
| AP4 |
| Increase SHP1 transcription in MCF-7 cell lines to reduce cell proliferation [81] | |
| NF1 |
| NF1/RFX1 binds to P sequence element of chorionic somatomammotropins gene promoter and represses its activity [162] | |
| ADD1 |
| Co-repressor of RFX1 in the COS-7 kidney fibroblast cell line [163] | |
| p107 |
| p107/ RFX1 utilized the RFX1 binding site and repressed PCNA [157] | |
| CREB |
| CCAR2 stabilizes RFX1/CREB complex which transcriptionally regulates cell cycle genes involved in cancer progression in HO1N1 SCC cell line [144] | |
| PP1c |
| Involved in RFX1 autorepression [87] | |
| HDAC |
| RFX1 recruits HDAC and represses COL1A2 promoter activity [64] | |
| mSin3A |
| RFX1 recruits mSin3A and represses COL1A2 promoter activity [64] |