Fig. 8

The hypoxia risk score was associated with the immune microenvironment. a Heatmap of related negative genes involved in the regulation of the cancer-immunity cycle in low and high risk groups in TCGA-BLCA. b Correlation between PD-1 expression and hypoxia risk score. c Correlation between PD-L1 expression and hypoxia risk score. d Correlation between CTLA-4 expression and hypoxia risk score. e Correlation between LAG-3 expression and hypoxia risk score. f Tumor immunosuppressive cytokine expression in low and high hypoxia risk groups. *p < 0.05, **p < 0.01, and ***p < 0.001