Fig. 6

Correlation between VWCE expression and immune infiltration level in breast cancer. a The prognostic significance of high and low expression of VWCE in breast cancers using the Kaplan–Meier plotter database. b The correlation between somatic copy number alterations (SCAN) and abundance of immune infiltrates of VWCE, including deep deletion, shallow deletion, diploid/normal, low-level gain, and high amplification. Box plots are presented to show the distributions of each TIIC subset for each copy number status in breast cancer using the same statistical tests as in the ‘‘mutation’’ module. Color images are available online. c Correlation analysis of VWCE expression and infiltration levels of immune cells in breast cancer using the TIMER database, including B cell abundance, CD8⁺ T cells, CD4⁺ T cells, macrophages, neutrophils, and dendritic cells relative to VWCE expression. d Correlation between VWCE expression and breast cancer prognosis in immune infiltration