Biogenesis, cellular effects, and biomarker value of circHIPK3

Fu, Yihan; Sun, Hong

doi:10.1186/s12935-021-01956-2

Cancer Cell International

Table 1 Different functions when circHIPK3 sponges different miRNAs in cancers

From: Biogenesis, cellular effects, and biomarker value of circHIPK3

Roles	Cancers	miRNA	mRNA/protein	Function	Refs.
Tumor promotor	Non-small cell lng cancer	miR124-3p	SphK1, CDK4	Proliferation	[94]
	Non-small cell lng cancer	miR124-3p	STAT3-PRKAA/AMPKalpha	Proliferation, migration, invasion, autophagy	[13]
		miR-149	FOXM1	growth, apoptosis, migration, invasion	[53]
		miR-379	IGF1	Proliferation	[73]
	Colorectal cancer	miR-637	STAT3/Bcl-2/beclin1	Autophagy, oxaliplatin-resistance	[100]
		miR-7	FAK, IGF1R, EGFR, YY1	Proliferation, migration, invasion, apoptosis	[95]
		miR-1207-5p	FMNL2	Proliferation, migration, invasion	[91]
	Cervical cancer	miR-338-3p	HIF-1	Growth, metastasis, EMT	[63]
	Gallbladder cancer	miR-124	ROCK1-CDK6	Proliferation, apoptosis	[33]
	Glioma	miR-124-3p	STAT3, WEEE1	Proliferation, invasion, EMT	[47, 85]
		miR-124-3p	CCND2	Proliferation, invasion	[47, 85]
		miR-654	IGF2BP3	Proliferation, invasion, tumor propagation	[31]
		miR-421	ZIC5	Invasion, apoptosis temozolomide (TMZ) resistance	[24, 25]
		miR-524-5p	KIF2A	Apoptosis, proliferation, metastasis, Temozolomide resistance	[93]
	Prostate cancer	miR338-3p	Cdc25B/Cdc2	G2/M transition, proliferation, apoptosis	[45]
		miR338-3p	ADAM17	Proliferative, invasive	[6]
		miR-193a-3p	MCL1	Proliferation, migration, invasion	[10]
	Oral squamous cell carcinoma	miR-124		Proliferation	[77]
	Oral squamous cell carcinoma	miR-381-3p	YAP1	Proliferation, invasion, migration, apoptosis	[4]
	Nasopharyngeal carcinoma	miR-4288	ELF3	Proliferation, migration, invasion	[34]
	Hepatocellular carcinoma	miR124	AQP3	Proliferation, migration	[12]
	Hepatocellular carcinoma	miR-582-3p	AQP3	Proliferation, migration, invasion, apoptosis	[97]
	Pancreatic cancer	miR-330-5p	RASSF1	Proliferation, invasive, migration, apoptosis, promotes Gemcitabine Resistance	[52]
	Breast cancer	miR-193a	HMGB1-PI3K-AKT	Proliferation, migration, invasion	[15]
	Breast cancer			Trastuzumab resistance	[98]
	Chronic myeloid leukemia				[21]
Tumor suppressor	Bladder cancer	miR-558	HPSE	Migration, invasion, angiogenesis	[41]
Tumor suppressor	Bladder cancer			Attenuate gemcitabine resistance	[87]

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ISSN: 1475-2867

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