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Fig. 1 | Cancer Cell International

Fig. 1

From: The mutual regulatory loop between TPTEP1 and miR-1303 in leukemogenesis of acute myeloid leukemia

Fig. 1

TPTEP1 impeded the proliferation of AML cells. a GEPIA 2 database suggested Transmembrane phosphatase with tensin homology pseudogene 1 (TPTEP1) was decreased in acute myeloid leukemia (AML) samples compared with the normal controls. b Relative expression of TPTEP1 in AML cell lines and the normal control HS-5 cells was analyzed by quantitative real-time polymerase chain reaction (qRT-PCR). c QRT-PCR result of TPTEP1 expression in HL60 and KG-1 cells under the transfection of pcDNA3.1 or pcDNA3.1/TPTEP1. d Cell proliferation was evaluated through cell counting kit-8 (CCK-8) assay. e, f The proliferation of HL60 and KG-1 cells under TPTEP1 upregulation or not was determined by 5-Ethynyl-2’-deoxyuridine (EdU) assays. (G-H) TUNEL assay was conducted to assess cell apoptosis rate of above cells. Data were presented as mean ± standard deviation (SD) (error bar). *P < 0.05, **P < 0.01

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