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Fig. 6 | Cancer Cell International

Fig. 6

From: hnRNPA2B1 regulates the alternative splicing of BIRC5 to promote gastric cancer progression

Fig. 6

Identification and validation of the hnRNPA2B1 target mRNAs in GC cells. a GO enrichment analysis of hnRNPA2B1 positively co-expressed genes (Pearson > 0.6, padj < 0.05) in cBioPortal TCGA dataset. b GO enrichment analysis of hnRNPA2B1 negatively co-expressed genes (Pearson < -0.6, padj < 0.05) in cBioPortal TCGA dataset. c The hnRNPA2B1 binding sites on BIRC5 mRNA by analyzing ENCORI database. d Schematic representation of the exons encoding three protein coding isoforms of BIRC5 in Ensembl. Arrows indicated the sites for qRT-PCR primers. e RIP-PCR analysis for the interaction of hnRNPA2B1 protein and BIRC5 mRNA. Data are presented as means ± S.D

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