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Fig. 7 | Cancer Cell International

Fig. 7

From: hnRNPA2B1 regulates the alternative splicing of BIRC5 to promote gastric cancer progression

Fig. 7

Overexpression of BIRC5-202 partially rescues the chemosensitivity of hnRNPA2B1-knockdown GC cells. a Expression levels of BIRC5-201, -202 and -203 mRNA in HGC-27 cells after transfection with control shRNA or hnRNPA2B1 shRNA. b pcDNA vector, pcDNA-BIRC5-202 or pcDNA-BIRC5-203 were transfected into HGC-27 cells and the expression of each isoforms were determined by qRT-PCR. c CCK8 assays were performed to determine cell growth in HGC-27 cells as treated in b. d Cell invasion ability of HGC-27 cells as treated in b. e BIRC5-202 was overexpressed in hnRNPA2B1 shRNA or shRNA control transfected HGC-27 cells. Cell viability was examined after cisplatin treatment for 48 h. f Correlation of BIRC5-202 and hnRNPA2B1 mRNA expression, as determined by qRT-PCR, in 29 GC samples. Data are presented as means ± S.D

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