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Fig. 5 | Cancer Cell International

Fig. 5

From: A novel autophagy-related genes prognostic risk model and validation of autophagy-related oncogene VPS35 in breast cancer

Fig. 5

VPS35 expression is upregulated in breast cancer and high expression levels of VPS35 proteins are associated with poor clinical outcomes of breast cancer patients. a The expression of VPS35 in breast cancer tissues and adjacent normal tissues at protein level. Lysates of tumor tissues (T) and matched adjacent noncancerous tissues (N) were analyzed using Western blotting. Eighteen representative pairs are shown. b The indicated protein levels in (a) were statistically analyzed. Relative protein expression across all samples. (***p < 0.001; middle). c The expression of VPS35 in normal breast epithelia MCF10A and various breast cancer cell lines (MCF‐7, ZR‐75‐1, MDA‐MB-231, Hs578T, SK-BR-3, MDA-MB-453). d Representative IHC staining with low expression of VPS35 in breast cancer tissue. e Representative IHC staining with high expression of VPS35 in breast cancer tissue. f The correlation of VPS35 expression with PFS of breast cancer patients by Kaplan–Meier survival analysis. g The correlation of VPS35 expression with OS of breast cancer patients by Kaplan–Meier survival analysis

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Cancer Cell International

ISSN: 1475-2867

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