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Fig. 1 | Cancer Cell International

Fig. 1

From: Mismatch repair-deficient hormone receptor-positive breast cancers: Biology and pathological characterization

Fig. 1

Schematic representation of the MMR system main components. MutSα complex (heterodimer MSH2-MSH6) initiates repair signaling by recognizing the mismatch (thunder). Then, MutLα (heterodimer MLH1-PMS2) is recruited, generating a ternary complex that mediates the downstream processes. Proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) are subsequently activated by MutS. In particular, RFC loads PCNA which is directly implicated in the excision repair and DNA synthesis process. The assembly will initiate endonuclease activity of PMS2 which creates single-strand breaks close to the mismatch and allows for the removal of the wrong-inserted base by exonuclease 1 (EXO1)

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Cancer Cell International

ISSN: 1475-2867

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