Table 1 Causes of MMR perturbation at the protein expression level in breast cancer according to the hormone receptor status
|  | HR+ (n = 69) | HR− (n = 12) |
|---|---|---|
MutS alone, n (%) | Â | Â |
MSH2 | 17 (25) | 3 (25) |
MSH6 | 4 (6) | 0 |
Both proteins | 6 (9) | 0 |
MutL alone, n (%) | Â | Â |
MLH1 | 10 (15) | 1 (8) |
PMS2 | 3 (4) | 0 |
Both proteins | 2 (3) | 1 (8) |
MutS + MutL, n (%) |  |  |
MutS + MLH1 | 4 (6) | 0 |
MutL + MSH2 | 2 (3) | 1 (8) |
MutL + MSH6 | 1 (2) | 0 |
MSH2 + MLH1 | 8 (12) | 4 (3) |
MSH2 + PMS2 | 1 (2) | 1 (8) |
MSH6 + MLH1 | 2 (3) | 0 |
MSH6 + PMS2 | 1 (2) | 0 |
All proteins | 8 (12) | 1 (8) |