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Table 3 Stratification and uni–multivariate analysis based on FST expression for survival of BCs

From: Down-regulated FST expression is involved in the poor prognosis of triple-negative breast cancer

Characteristics No. of cases HR of OS (95% CI) p-value Adjusted Adjusted
HR of OSa (95% CI) p-value
Pathological stage#
 I/II 689 0.45 (0.22–0.93) 0.031* 0.32 (0.15–0.70) 0.004*
 III/IV 236 0.37 (0.14–0.97) 0.043* 0.49 (0.17–1.46) 0.203
Lymph node#
 Negative 427 0.37 (0.15–0.89) 0.026* 0.23 (0.09–0.62) 0.003*
 Positive 490 0.35 (0.15–0.84) 0.018* 0.46 (0.18–1.19) 0.109
Distant metastasis#
 Negative 771 0.41 (0.22–0.75) 0.004* 0.35 (0.18–0.68) 0.002*
 Positive 18 0.67 (0.08–5.63) 0.713 0.83 (0.10–7.20) 0.867
PR status#
 Negative 161 NA 0.809 NA 0.996
 Positive 772 0.49 (0.28–0.86) 0.013* 0.42 (0.23–0.78) 0.006*
Molecular subtype
 HR positive 808 0.46 (0.25–0.85) 0.012* 0.39 (0.21–0.75) 0.005*
 HER–2 positive 36 0.19 (0.03–1.42) 0.105 0.26 (0.04–1.97) 0.194
 TNBC 91 3.85 (0.83–17.93) 0.086 6.39 (0.78–52.34) 0.084
Histological subtype#
 Infiltrating ductal BC 655 0.40 (0.21–0.78) 0.007* 0.43 (0.21–0.90) 0.025*
 Infiltrating lobular BC 192 0.29 (0.04–1.89) 0.194 0.08 (0.01–0.57) 0.012*
 Mixed BC 24 NA NA NA NA
 Medullary BC 3 NA NA NA NA
 Metaplastic BC 5 NA NA NA NA
 Mucinous BC 16 NA NA NA NA
 Others 39 0.72 (0.13–3.98) 0.703 0.77 (0.14–4.33) 0.770
  1. aAjusted HR, adjusted by age and ethnicity in COX analysis; #The composition ratio is less than 100%; *p < 0.05, statistical significance