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Table 3 Stratification and uni–multivariate analysis based on FST expression for survival of BCs

From: Down-regulated FST expression is involved in the poor prognosis of triple-negative breast cancer

Characteristics

No. of cases

HR of OS (95% CI)

p-value

Adjusted

Adjusted

HR of OSa (95% CI)

p-value

Pathological stage#

 I/II

689

0.45 (0.22–0.93)

0.031*

0.32 (0.15–0.70)

0.004*

 III/IV

236

0.37 (0.14–0.97)

0.043*

0.49 (0.17–1.46)

0.203

Lymph node#

 Negative

427

0.37 (0.15–0.89)

0.026*

0.23 (0.09–0.62)

0.003*

 Positive

490

0.35 (0.15–0.84)

0.018*

0.46 (0.18–1.19)

0.109

Distant metastasis#

 Negative

771

0.41 (0.22–0.75)

0.004*

0.35 (0.18–0.68)

0.002*

 Positive

18

0.67 (0.08–5.63)

0.713

0.83 (0.10–7.20)

0.867

PR status#

 Negative

161

NA

0.809

NA

0.996

 Positive

772

0.49 (0.28–0.86)

0.013*

0.42 (0.23–0.78)

0.006*

Molecular subtype

 HR positive

808

0.46 (0.25–0.85)

0.012*

0.39 (0.21–0.75)

0.005*

 HER–2 positive

36

0.19 (0.03–1.42)

0.105

0.26 (0.04–1.97)

0.194

 TNBC

91

3.85 (0.83–17.93)

0.086

6.39 (0.78–52.34)

0.084

Histological subtype#

 Infiltrating ductal BC

655

0.40 (0.21–0.78)

0.007*

0.43 (0.21–0.90)

0.025*

 Infiltrating lobular BC

192

0.29 (0.04–1.89)

0.194

0.08 (0.01–0.57)

0.012*

 Mixed BC

24

NA

NA

NA

NA

 Medullary BC

3

NA

NA

NA

NA

 Metaplastic BC

5

NA

NA

NA

NA

 Mucinous BC

16

NA

NA

NA

NA

 Others

39

0.72 (0.13–3.98)

0.703

0.77 (0.14–4.33)

0.770

  1. aAjusted HR, adjusted by age and ethnicity in COX analysis; #The composition ratio is less than 100%; *p < 0.05, statistical significance