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Fig. 4 | Cancer Cell International

Fig. 4

From: circ-PTK2 (hsa_circ_0008305) regulates the pathogenic processes of ovarian cancer via miR-639 and FOXC1 regulatory cascade

Fig. 4

Circ-PTK2 was identified as the candidate circRNA involved in ovarian cancer after CHD1L was inhibited. A Cluster graph in presenting the expression profiles of SK-OV-3 cells with si-CHD1L or si-NC treatment. B Dot plots of differentially expressed circRNAs, with upregulated expression of 82 circRNAs and downregulated expression of 247 circRNA. C Divergent and convergent primers for PCR and Sanger sequencing to validate the circular structure of the candidate circular RNAs. D Fluorescent in situ hybridization validation of the expression level of circ-PTK2. E Reverse transcriptase-quantitative PCR validation of the level of circ-PTK2 in SK-OV-3 and OVCAR-3 cells after inhibition of CHD1L expression. Data are presented as the mean ± SD. **P < 0.01

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Cancer Cell International

ISSN: 1475-2867

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