Table 2 The biological functions and molecular mechanisms of LINC00261
From: LINC00261: a burgeoning long noncoding RNA related to cancer
Cancer type | Property | Functional role(validated) | Related genes/proteins/pathways | PMID |
|---|---|---|---|---|
Pancreatic cancer | Suppressor | EMT, motility, invasiveness | FOXA2, Wnt pathway | 32,414,223 |
Metastasis | Wnt, miR5525p/FOXO3 | 32,020,223 | ||
Proliferation, metastasis | c-Myc, MYC, E2F | 32,929,371 | ||
Progression | FOXA2, cAMP and MAPK | 32,590,069 | ||
Cell-cycle arrest, proliferation | IGF2BP1, HIPK2/ERK | 33,122,827 | ||
Gastric cancer | Suppressor | EMT | Focal adhesion | 27,439,973 |
EMT | Ubiquitin-proteasome | 27,878,953 | ||
Colon cancer | Suppressor | Drug resistant, apoptosis, viability | Wnt/β-catenin | 29,267,503 |
Progression | miR-324‐3p, Wnt/β‐catenin | 31,183,860 | ||
Lung cancer | Suppressor | EMT | / | 31,115,010 |
Cell proliferation, invasion, and apoptosis | miR-522‐3p, Wnt | 31,190,356 | ||
Metastasis and proliferation | FHL1 | 31,772,674 | ||
Tumorigenesis, and progression | FOXA2, ERK pathway | 30,597,925 | ||
Proliferation and metastasis | Wnt/β-catenin, miR-1269a/FOXO1 | 32,607,060 | ||
Migration, and proliferation | FOXA2 | 30,796,052 | ||
Hepatocellular carcinoma | Suppressor | Proliferation, invasion, EMT | Notch signaling pathway | 29,278,875 |
/ | PPAR signaling pathway | 29,761,859 | ||
Metastasis, migration, invasion, and EMT | FOXA2, TGF-β signaling | 33,520,374 | ||
Migration, and invasion | / | 30,377,132 | ||
Breast cancer | Suppressor | Cell viability, microsphere formation ability, migration, and invasion | / | 33,274,565 |
Proliferation, migration, and tumorigenesis | NME1-EMT pathway | 32,440,206 | ||
Laryngeal carcinoma | Suppressor | / | / | 29,774,690 |
Endometrial carcinoma | Suppressor | Proliferation, migration, and invasion | / | 30,019,459 |
Esophageal cancer | Suppressor | Chemotherapeutic response | Metabolic pathway | 30,226,808 |
Prostate cancer | Suppressor | Proliferation, angiogenesis | p38 MAPK, Wnt/β-catenin | 33,013,201 |
Choriocarcinoma | Suppressor | Proliferation, EMT, and cell apoptosis | / | 27,983,929 |
Cholangiocarcinoma | Oncogene | Metastasis, and EMT | / | 31,812,439 |