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Fig. 5 | Cancer Cell International

Fig. 5

From: YWHAE as an HE4 interacting protein can influence the malignant behaviour of ovarian cancer by regulating the PI3K/AKT and MAPK pathways

Fig. 5

Effect of YWHAE on proliferation, apoptosis, and cell cycle of ovarian cancer cells. a YWHAE overexpression promoted the proliferation of OVCAR3 and A2780 ovarian cancer cells, as determined via MTT assay; b YWHAE knockdown inhibited the proliferation of CAOV3 and ES2 ovarian cancer cells, as determined via MTT assay. c, d Ovarian cells passed into G2/M phases following YWHAE overexpression; e, f G0/G1 phase arrested following YWHAE siRNA transfection; g, h YWHAE overexpression decreased apoptosis of OVCAR3 and A2780 cells; i, j YWHAE knockdown increased apoptosis of CAOV3 and ES2 cells

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Cancer Cell International

ISSN: 1475-2867

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