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Fig. 4 | Cancer Cell International

Fig. 4

From: Vesicle transporter GOLT1B mediates the cell membrane localization of DVL2 and PD-L2 and promotes colorectal cancer metastasis

Fig. 4

GOLT1B induces EMT via regulating Wnt/β-catenin pathway. a Heatmap shows the significantly altered 531 genes (P < 0.05, fold change ≥ 1.5) after knocking down of GOLT1B in HCT116 cells (supplementing the detailed gene in Table S2). b, c KEGG and GO analyses of differential expression genes on Dr. Tom platform (BGI-tech, China). d, e GSEA enrichment analysis of differentially expressed genes. f EMT-related gene expression was determined by western blot after downregulation of GOLT1B. g The dual luciferase report experiment showed that overexpression of GOLT1B in HCT116 can activate the Wnt signaling pathway. h Activation of Wnt signaling pathway were analyzed by Western blot analysis

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