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Table 2 Univariate and multivariate analysis of different parameters for overall survival in CRC patients

From: Vesicle transporter GOLT1B mediates the cell membrane localization of DVL2 and PD-L2 and promotes colorectal cancer metastasis

Variables Univariate analysis Multivariate analysis
  HR (95%CI) P value HR (95%CI) P value
Gender (male vs female) 0.881 (0.526–1.477) 0.632   
Age (≥ 67 vs < 67) 1.929 (1.135–3.281) 0.015* 1.318 (0.749–2.318) 0.338
pT status (T3-T4 vs T1-T2) 7.270 (2.635–20.057) < 0.001*** 3.004 (1.004–8.989) 0.049*
pN status (N1-N2 vs N0) 7.164 (4.201–12.217) < 0.0001**** 2.690 (1.429–5.065) 0.0022**
pM status (M1 vs M0) 15.165 (8.692–26.456) < 0.0001**** 6.337 (3.387–11.859)  < 0.0001****
Histological grade (G3 vs G1-G2) 0.594 (0.335–1.054) 0.075 1.144 (0.620–2.109) 0.667
Recurrence (YES vs NO) 1.752 (0.701–4.382) 0.230   
GOLT1B expression (High vs Low) 5.089 (2.189–11.834) < 0.001*** 2.520 (1.034–6.142) 0.042*
  1. Univariate and multivariate Cox proportional hazards regression were used to calculate Hazard ratio (HR), 95% confidence intervals (95% CI) and p values in SPSS 24.0. Low GOLT1B is defined as IHC score < 5 and High GOLT1B is defined as IHC score ≥ 5. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001