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Fig. 5 | Cancer Cell International

Fig. 5

From: LncRNA WDFY3-AS2 promotes cisplatin resistance and the cancer stem cell in ovarian cancer by regulating hsa-miR-139-5p/SDC4 axis

Fig. 5

LncRNA WDFY3-AS2 upregulated SDC4 expression by sponging miR-139-5p in OC A2780-DDP cells. A Dual luciferase reporter assay validated miR-139-5p binding to SDC4. B RNA pull-down confirmed that the binding of miR-139-5p and SDC4 by the miR-139-5p-biotin. C qRT-PCR expression analysis of SDC4 in OC A2780-DDP cells. D Western blotting assessment of SDC4 protein expression in OC A2780-DDP cells. E The negative correlation between miR-139-5p and SDC4, n = 15. F, G, The mRNA and protein expression of SDC4 in si-WDFY3-AS2 transfected cells with co-transfection of miR-139-5p inhibitor. ###P < 0.001 vs. si-WDFY3-AS2 + inhibitor NC, ***P < 0.001 vs. control

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