Fig. 2From: Mitochondrial pyruvate carrier 1: a novel prognostic biomarker that predicts favourable patient survival in cancerThe function of MPC1 in mitochondria. Oestrogen-related receptor-alpha (ERR-α) activates the proximal MPC1 promoter through PGC-1α, thus causing MPC1 overexpression. PGC-1α promotes MPC1 expression, enhancing pyruvate transport and OXPHOS activityBack to article page