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Fig. 3 | Cancer Cell International

Fig. 3

From: IFI35 is involved in the regulation of the radiosensitivity of colorectal cancer cells

Fig. 3

Effect of IFI35 on X-ray irradiation and cell apoptosis of colorectal cancer cells. A Flow cytometry detection of the effect of IFI35 on the cell apoptosis of colorectal cancer cells. The bar graph shows the proportion of apoptotic cells. Overexpressing IFI35 increases cancer cell apoptosis, wile inhibiting IFI35 decreases cancer cell apoptosis. B Expression of apoptosis-related proteins Bax, Caspase-3, Caspase-9, and Bcl-2 determined by Western blot. The bar graphs show the protein expression normalized to that of GAPDH. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Ad-NC: adenovirus, negative control; Ad-IRF1, adenovirus for IRF1 overexpression; sh: short hairpin RNA for the downregulation of IRF1 or IFI35. shNC: negative control short hairpin RNA

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