The emerging role of circular RNAs in common solid malignant tumors in children

Yu, Jiabin; Yang, Li; Lu, Hongting

doi:10.1186/s12935-021-01998-6

Cancer Cell International

Table 1 Role of circRNAs in solid malignant tumors (SMTs) in children

From: The emerging role of circular RNAs in common solid malignant tumors in children

SMTs in children	CircRNA	Expression	Target gene/protein	Biological function	Ref
Osteosarcoma	Circ_0001105	Down	MiR-766/YTHDF2	Inhibit proliferation, migration, and invasion	[19]
	CircTADA2A	Up	MiR-203a-3p/CREB3	Promote progression and metastasis	[20]
	CircMYO10	Up	MiR-370-3p/RUVBL1	Promote proliferation and EMT	[21]
	Circ-0008717	Up	MiR-203	Promote proliferation, migration, and invasion	[22]
	CircFAT1	Up	MiR-375/YAP1	Promote migration, invasion, and tumorigenesis	[23]
	Hsa_circ_0000282	Up	miR-192/XIAP	Promote proliferation	[24]
	circ_0001649	Down	MiR-338-5p/miR-647/miR-942	Inhibit proliferation, migration; induce apoptosis	[25]
Glioma	Circ_002136	Up	MiR-138-5p/SOX13	Promote angiogenesis	[26]
	CircHIPK3	Up	MiR-124-3p	Promote proliferation, migration, and invasion; inhibit apoptosis	[27]
			MiR-654/IGF2BP3	Promote proliferation, migration, and invasion	[28]
Neuroblastoma	CircAGO2	Up		Promote proliferation, migration, and invasion	[29]
	CircCUX1	Up	EWSR1/MAZ	Induce the aerobic glycolysis	[30]
	CircCUX1	Up	miR-16-5p/DMRT2	Promote proliferation, migration, invasion, and glycolysis	[31]
Hepatoblastoma	Circ_0015756	Up	MiR-1250-3p	Promote proliferation and invasion	[32]
	CircHMGCH1	Up	MiR-503-5p/IGF2	Promote proliferation	[33]
	CircSTAT3	Up	MiR-29a/b/c-3p	Promote proliferation, invasion, migration, stemness	[34]
Infantile hemangioma	Hsa_circ_100933	Up			[35]
	Hsa_circ_100709	Up			[35]
	Hsa_circ_104310	Down			[35]
	CircAP2A2	Up	MiR-382-5p/VEGFA	Promote proliferation, migration, and invasion	[37]
Rhabdomyosarcoma	Circ-ZNF609	Up		Regulate G1-S progression	[38]
Retinoblastoma	Circ-0075804	Up	E2F3	Promote proliferation	[39]
	CircVAPA	Up	miR-615-3p/SMARCE1	Promote proliferation, migration, and invasion	[40]
	Hsa_circ_0001649	Up	AKT	Promote proliferation, migration, and invasion; inhibit apoptosis	[41]
Wilms’ tumor	Circ_0017247	Up	MiR-145	Induce metastasis	[42]
Medulloblastoma	Circ-SKA3	Up		Promote the proliferation, migration and invasion	[43]
Medulloblastoma	Circ-DTL	Up		Promote the proliferation, migration and invasion	[43]

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ISSN: 1475-2867

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