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Table 1 Role of circRNAs in solid malignant tumors (SMTs) in children

From: The emerging role of circular RNAs in common solid malignant tumors in children

SMTs in children CircRNA Expression Target gene/protein Biological function Ref
Osteosarcoma Circ_0001105 Down MiR-766/YTHDF2 Inhibit proliferation, migration, and invasion [19]
CircTADA2A Up MiR-203a-3p/CREB3 Promote progression and metastasis [20]
CircMYO10 Up MiR-370-3p/RUVBL1 Promote proliferation and EMT [21]
Circ-0008717 Up MiR-203 Promote proliferation, migration, and invasion [22]
CircFAT1 Up MiR-375/YAP1 Promote migration, invasion, and tumorigenesis [23]
Hsa_circ_0000282 Up miR-192/XIAP Promote proliferation [24]
circ_0001649 Down MiR-338-5p/miR-647/miR-942 Inhibit proliferation, migration; induce apoptosis [25]
Glioma Circ_002136 Up MiR-138-5p/SOX13 Promote angiogenesis [26]
CircHIPK3 Up MiR-124-3p Promote proliferation, migration, and invasion;
inhibit apoptosis
[27]
   MiR-654/IGF2BP3 Promote proliferation, migration, and invasion [28]
Neuroblastoma CircAGO2 Up   Promote proliferation, migration, and invasion [29]
CircCUX1 Up EWSR1/MAZ Induce the aerobic glycolysis [30]
Up miR-16-5p/DMRT2 Promote proliferation, migration, invasion, and glycolysis [31]
Hepatoblastoma Circ_0015756 Up MiR-1250-3p Promote proliferation and invasion [32]
CircHMGCH1 Up MiR-503-5p/IGF2 Promote proliferation [33]
CircSTAT3 Up MiR-29a/b/c-3p Promote proliferation, invasion, migration, stemness [34]
Infantile hemangioma Hsa_circ_100933 Up    [35]
Hsa_circ_100709 Up    [35]
Hsa_circ_104310 Down    [35]
CircAP2A2 Up MiR-382-5p/VEGFA Promote proliferation, migration, and invasion [37]
Rhabdomyosarcoma Circ-ZNF609 Up   Regulate G1-S progression [38]
Retinoblastoma Circ-0075804 Up E2F3 Promote proliferation [39]
CircVAPA Up miR-615-3p/SMARCE1 Promote proliferation, migration, and invasion [40]
Hsa_circ_0001649 Up AKT Promote proliferation, migration, and invasion;
inhibit apoptosis
[41]
Wilms’ tumor Circ_0017247 Up MiR-145 Induce metastasis [42]
Medulloblastoma Circ-SKA3 Up   Promote the proliferation, migration and invasion [43]
Circ-DTL Up   Promote the proliferation, migration and invasion [43]