Fig. 7
From: Utilizing the Hippo pathway as a therapeutic target for combating endocrine-resistant breast cancer
Illustration of miRNAs in regulation of the Hippo pathway. MiRNAs dysregulate the Hippo pathway by inhibiting LATS and phosphorylation of YAP, or directly upregulating YAP and TAZ. MiR-520b, miR-372, miR-31, miR-93, miR-135b and miR-515-5p are tumor promotors with the dysregulation of the Hippo pathway. On the contrary, miR-199a-3p, miR-591, miR-18a, miR-506, miR-424, miR-146b, miR-574-5p, miR-205, miR-125a-5p, miR-1297 and miR-326 are tumor suppressors with the activation of the Hippo pathways