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Table 5 MiRNAs that regulate the Hippo pathway in breast cancer

From: Utilizing the Hippo pathway as a therapeutic target for combating endocrine-resistant breast cancer

MiRNAs

Tumor suppressor (−)/tumor promotor (+)

Cell lines

Targets

Mechanisms of regulation

MiR-326 [142]

MCF-7, MDA-MB-468

TAZ

Circular RNA 0000511 can eliminate the anti-tumor effect of miR-326 by upregulating TAZ

MiR-146b [143]

MCF-7

p-YAP

The process of MUC19 reducing YAP phosphorylation is inhibited by miR-146b

MiR-199a-3p [133]

MDA-MB-231

LATS1, YAP1

miR-199a-3p suppresses YAP1 and upregulates LATS1

MiR-574-5p [135]

MDA-MB-231, T47D

TAZ

miR-574-5p targets Sox2 to suppress TAZ

MiR-1297 [144]

MDA-MB-231, MDA-MB-468

TAZ

miR-1297 inhibits TAZ

MiR-125a-5p [145, 146]

MDA-MB-468, BT549, tamoxifen resistant MCF7

TAZ

miR-125a-5p directly inhibits TAZ expression. Downregulation of CYTOR decreases protein and mRNA levels of TAZ in tamoxifen resistant MCF7 cells, which is rescued by miR-125a-5p suppression

MiR-515-5p [147]

 + 

MDA-MB-231, MDA-MB-453

YAP, TAZ, p-TAZ

Knockdown LINC00673 reduces the level of YAP/TAZ and increases p-YAP through miR-515-5p inactivation

MiR-591 [148]

MCF-7, SKBR3

YAP, LATS

miR-591 inhibits YAP and upregulates LATS

MiR-520b [94]

 + 

MCF-7, MDA-MB-231

LATS2, p-YAP, YAP

miR-520b promotes migration activity and stemness of breast cancer, which can be abolished by overexpression of LATS2. miR-520b upregulates nuclear YAP and inhibits LATS2 as well as p-YAP

MiR-372 [149]

 + 

MCF-7, MDA-MB-231

LATS2

miR-372 inhibits LATS2

MiR-18a [150]

Trastuzumab-resistant SKBR-3

YAP1

miR-18a directly inhibits YAP1

MiR-424 [151]

MDA-MB-231, HCC-1937

YAP

miR-424 inhibits YAP

MiR-205 [134]

SUM159

TAZ

miR-205 inhibits TAZ, which is involved in the mammospheres formation and BCSC renewal

MiR-135b [152]

 + 

MDA-MB-231, MCF-7, 293 T

LATS2,

miR-135b inhibits LATS2

MiR-506 [153]

MDA-MB-231

YAP

miR-506 inhibits YAP

MiR-31 [154]

 + 

MDA-MB-231

LATS2

miR-31 inhibits LATS2

MiR-93 [155]

 + 

MT-1

LATS2

miR-93 inhibits LATS2