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Fig. 3 | Cancer Cell International

Fig. 3

From: CircRNA NALCN acts as an miR-493-3p sponge to regulate PTEN expression and inhibit glioma progression

Fig. 3

circNALCN suppresses the proliferation and migration of glioma cells. A qRT-PCR analysis of circNALCN expression in U87 and U251 cells overexpressing circNALCN. B qRT-PCR analysis of circNALCN expression in U87 and U251 treated with siRNAs. C, D CCK-8 experiment detecting the proliferation ability of U87 and U251 cells transfected with vector, oe-circNALCN, si-NC, or si-circNALCN. E, F The migration abilities of U87 and U251 cells transfected with vector, oe-circNALCN, si-NC, or si-circNALCN were detected by Transwell assay. G, H The migration abilities of U87 and U251 cells transfected with vector, oe-circNALCN, si-NC, or si-circNALCN was detected by wound healing assay. Scale bar: 100 µm. Data are presented as the mean ± SD; ns indicates no significance, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Vector: empty vector control; oe-circNALCN: circNALCN overexpression vector; si-NC: negative control siRNA; si-circNALCN: circNALCN siRNA

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