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Fig. 9 | Cancer Cell International

Fig. 9

From: Overexpression of DDIT4 and TPTEP1 are associated with metastasis and advanced stages in colorectal cancer patients: a study utilizing bioinformatics prediction and experimental validation

Fig. 9

Evaluation cancer stem cell (CSC) features in colorectal CSC-enriched spheroids. Morphological feature of HT-29 cancer cells (A) and colorectal CSC-enriched spheroids derived from HT-29 cells (B). Overexpression of stemness genes (OCT4, SOX2, C-MYC, KLF4, and NANOG), (C), ABC transporter genes (ABCB1, ABCG2, and ABCC1) (D) and epithelial-mesenchymal transition (EMT) genes (TWIST1, SNAIL1, Vimentin (VIM), and ZEB1) (E) in colorectal CSC-enriched spheroids compared to HT-29 cancer cells as control. Not significant (ns): P > 0.05, *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001

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Cancer Cell International

ISSN: 1475-2867

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