Overexpression of DDIT4 and TPTEP1 are associated with metastasis and advanced stages in colorectal cancer patients: a study utilizing bioinformatics prediction and experimental validation

Table 4 Relationship between RNA expression of genes and clinicopathological features from colorectal cancer samples

Clinicopathological features	Relevant expression of genes (2 ^−ΔΔCt), p-value
Clinicopathological features	DDIT4	SULF1	TPTEP1	miR-181d-5p	miR-148b-3p
Tumor size (cm) , mean ≈ 5 cm
\(\le\) 5	0.689	0.468	0.076	0.430	0.556
\(>\) 5	0.689	0.468	0.076	0.430	0.556
Vascular invasion
Yes	0.273	0.133	0.193	0.280	0.315
No	0.273	0.133	0.193	0.280	0.315
Perineural invasion
Yes	0.752	0.549	0.966	0.058	0.021*
No	0.752	0.549	0.966	0.058	0.021*
TNM stage
I-II	0.354	0.023*	< 0.01*	0.920	0.359
III-IV	0.354	0.023*	< 0.01*	0.920	0.359
Metastasis
No metastasis	0.048*	0.009*	0.035*	0.681	0.226
Only lymph node metastasis
Distant metastasis
Histologic grade (Tumor differentiation)
Grade 1 (Low)	0.922	0.215	0.978	0.016*	0.062
Grade 2 (Moderately)
Grade 3 (Poorly)

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