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Fig. 4 | Cancer Cell International

Fig. 4

From: Exosomal circRNA as a novel potential therapeutic target for multiple myeloma-related myocardial damage

Fig. 4

Construction of a circRNA-miRNA-mRNA interaction network and verification with a luciferase assay. A The circRNA-miRNA-mRNA network predicted by miRanda and TargetScan presented as a map constructed with Cytoscape software. B The binding sites between TLR4, hsa-miR-4268 and circ-G042080. C The luciferase assay results showed that hsa-miR-4268 mimics significantly reduced the luciferase activity in the circ-G042080 WT group compared with that in the HC group (Pā€‰<ā€‰0.05) but had no effect in the circ-G042080 MUT group. D Luciferase activity results showed that hsa-miR-4268 mimics reduced the luciferase activity in the TLR4 WT group (Pā€‰<ā€‰0.05) but had no effect on the luciferase activity in the TLR4 MUT group

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