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Fig. 5 | Cancer Cell International

Fig. 5

From: Exosomal circRNA as a novel potential therapeutic target for multiple myeloma-related myocardial damage

Fig. 5

circ-G042080 is positively correlated with the clinical features of MM-related myocardial damage and is a potential prognostic indicator of MM-related myocardial damage. A circ-G042080 was found to be positively correlated with TnT (R2 = 0.534) and proBNP levels (R2 = 0.653). B circ-G042080 was negatively correlated with EF (R2 = 0.639) and SBP levels (R2 = 0.321). C ROC curve analysis showed that the level of circ-G042080 had high sensitivity and specificity for determination of the prognosis of patients with MM-related myocardial damage. The area under the curve (AUC) and optimal cutoff value of circ-G042080 were 0.09 and 2.18, respectively. D PCR verified the relationship between the serum exosome circ-G042080 level and the NYHA score in MM patients. E PCR verified the relationship between the serum exosomal circ-G042080 level and BNP level in MM patients

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