Fig. 4
RSF1 interactions and functions involved in cancer. a RSF1 interacts with ATM and is phosphorylated by ATM, then to interact with CENP-S/MHF1 to recruit FANCI/FANCD2 at DSBs to promote DNA HR repair, RSF1 interacts with ATM and is phosphorylated by ATM to decrease the upregulated protein level of RSF1 upon DNA damage. b RSF1 interacts with HBX and BubR1 to recruit HBX at kinetochore to decrease BubR1-Cdc20 interaction to inhibit metaphase-to-anaphase mitotic checkpoint. c RSF1 interacts with H2Aub to suppress oncogene transcription. d over-expressed RSF1 recruits CBP to interact with NF-κB, and then activate NF-κB induced transcription to increase chemoresistance. e RSF1 interacts with and recruits PLK1 to kinetochore to phosphorylate BubR1 to maintain accurate chromosome arrangement. f RSF1 interacts with cyclin E1 to increase CDK2 activity to inhibit G1/S checkpoint. g RSF1 recruits CENP-A to centromere to maintain accurate chromosome segregation. h RSF1 interacts with and recruits HDAC1 to centromere to protect centromeric cohesion. i RSF1 interacts with SNF2H to make SNF2H enter nucleus to stabilize SNF2H, RSF1 interacts with SNF2H to maintain the protein homeostasis of RSF1 in the absence of DNA damage, over-expressed RSF1 interacts with SNF2H to promote tumor growth