From: Functional interplay between long non-coding RNAs and the Wnt signaling cascade in osteosarcoma
LncRNA | Expression pattern | Interaction with Wnt pathway | Target genes | Associated clinical values | Cellular physiological functions | Regulatory modality | Refs. |
---|---|---|---|---|---|---|---|
AFAP1-AS1 | ↑ | Activating Wnt/β-catenin | miR-4695-5p/TCF4 | Prognosis | Proliferation, invasion | Transcriptional | [157] |
AWPPH | ↑ | Activating Wnt/β-catenin | miR-93-3p/FZD7 | Advanced stage, tumor size, metastasis, survival | Proliferation, migration, invasion | Transcriptional | [148] |
BE503655 | ↑ | Activating Wnt/β-catenin | - | Enneking stage, DM, histological grade | Proliferation, cell cycle, invasion, migration | Unknown | [63] |
C2dat1 | ↑ | Activating Wnt/β-catenin, p38/ERK/AKT | miR-34a-5p/Sirt1 | - | Cell viability, migration, invasion, apoptosis | Transcriptional | [104] |
CAT104 | ↑ | Activating Wnt/β-catenin, JNK | miR-381/ZEB1 | - | Proliferation, migration, invasion, apoptosis | Transcriptional | [89] |
CRNDE | ↑ | Activating Wnt/β-catenin | GSK-3β | - | Proliferation, invasion, apoptosis, cell cycle arrest, EMT | Post-transcriptional | [107] |
DLX6-AS1 | ↑ | Activating Wnt | miR-129-5p/DLK1 | Prognosis | Stemness | Transcriptional | [123] |
DSCAM-AS1 | ↑ | Activating Wnt/β-catenin and AKT/mTOR | miR-101-3p/USP47 | - | Proliferation, migration, invasion, apoptosis | Transcriptional | [84] |
FLVCR1-AS1 | ↑ | Activating Wnt/β-catenin | CTNNB1, SOX4, CCND1, CCND2, Myc | Tumor size, WHO grade, DM, survival | Proliferation, migration and invasion | Unknown | [145] |
GHET1 | ↑ | Activating Wnt/β-catenin | - | - | Proliferation, migration, invasion, EMT, apoptosis | Unknown | [106] |
HNF1A-AS1 | ↑ | Activating Wnt/β-catenin | - | Clinical stage, DM, overall survival | Proliferation, metastasis | Unknown | [149] |
HOTTIP | ↑ | Activating Wnt/β-catenin | - | Chemoresistance | Proliferation, cell cycle, cisplatin resistance | Unknown | [119] |
ITGB2-AS1 | ↑ | Activating Wnt/β-catenin | - | Prognosis | Proliferation, apoptosis, migration, invasion | Unknown | [153] |
LEF1-AS1 | ↑ | Activating Wnt | HNRNPL/LEF1 | - | Proliferation, migration, invasion | Transcriptional | [64] |
LINC01128 | ↑ | Activating Wnt/β-catenin | miR-299-3p/MMP2 | - | Proliferation, migration, and invasion | Transcriptional | [75] |
Lnc-MAP6-1:3 | ↑ | Activating Wnt/β-catenin and Bax/Bcl-2 | - | - | Proliferation, apoptosis | Post-transcriptional | [85] |
LncSox4 | ↑ | Activating β-catenin | - | - | Viability, migration | Post-transcriptional | [103] |
LSINCT5 | ↑ | Activating β-catenin | EZH2/APC | Prognosis | Proliferation, tumor growth | Transcriptional | [152] |
MEG3 | ↓ | Inhibit Wnt/β-catenin | miR-184/TCF4 and c-Myc | - | Cell viability, metastasis, apoptosis | Transcriptional | [187] |
TMPO-AS1 | ↑ | Activating Wnt/β-catenin | miR-199a-5p/WNT7B | - | Proliferation, apoptosis | Transcriptional | [86] |
SNHG1 | ↑ | Activating Wnt/β-catenin | miR-577/WNT2B | Tumor size, TNM stage, LNM | Proliferation, migration, EMT | Transcriptional | [146] |
SNHG10 | ↑ | Activating Wnt/β-catenin | miR-182-5p/FZD3 | - | Proliferation, invasion | Transcriptional | [77] |
TUG1 | ↑ | Activating Wnt/β-catenin | miR-144-3p/EZH2 | - | Proliferation, migration, invasion, apoptosis | Transcriptional | |
UCA1 | ↑ | Activating Wnt/β-catenin and NF-κB | miR-301a/CXCR4 | - | Cell viability, migration, invasion, apoptosis | Transcriptional |