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Table 1 Overview of Wnt signaling pathway-related lncRNAs in development of osteosarcoma

From: Functional interplay between long non-coding RNAs and the Wnt signaling cascade in osteosarcoma

LncRNA

Expression pattern

Interaction with Wnt pathway

Target genes

Associated clinical values

Cellular physiological functions

Regulatory modality

Refs.

AFAP1-AS1

↑

Activating Wnt/β-catenin

miR-4695-5p/TCF4

Prognosis

Proliferation, invasion

Transcriptional

[157]

AWPPH

↑

Activating Wnt/β-catenin

miR-93-3p/FZD7

Advanced stage, tumor size, metastasis, survival

Proliferation, migration, invasion

Transcriptional

[148]

BE503655

↑

Activating Wnt/β-catenin

-

Enneking stage, DM, histological grade

Proliferation, cell cycle, invasion, migration

Unknown

[63]

C2dat1

↑

Activating Wnt/β-catenin, p38/ERK/AKT

miR-34a-5p/Sirt1

-

Cell viability, migration, invasion, apoptosis

Transcriptional

[104]

CAT104

↑

Activating Wnt/β-catenin, JNK

miR-381/ZEB1

-

Proliferation, migration, invasion, apoptosis

Transcriptional

[89]

CRNDE

↑

Activating Wnt/β-catenin

GSK-3β

-

Proliferation, invasion, apoptosis, cell cycle arrest, EMT

Post-transcriptional

[107]

DLX6-AS1

↑

Activating Wnt

miR-129-5p/DLK1

Prognosis

Stemness

Transcriptional

[123]

DSCAM-AS1

↑

Activating Wnt/β-catenin and AKT/mTOR

miR-101-3p/USP47

-

Proliferation, migration, invasion, apoptosis

Transcriptional

[84]

FLVCR1-AS1

↑

Activating Wnt/β-catenin

CTNNB1, SOX4, CCND1, CCND2, Myc

Tumor size, WHO grade, DM, survival

Proliferation, migration and invasion

Unknown

[145]

GHET1

↑

Activating Wnt/β-catenin

-

-

Proliferation, migration, invasion, EMT, apoptosis

Unknown

[106]

HNF1A-AS1

↑

Activating Wnt/β-catenin

-

Clinical stage, DM, overall survival

Proliferation, metastasis

Unknown

[149]

HOTTIP

↑

Activating Wnt/β-catenin

-

Chemoresistance

Proliferation, cell cycle, cisplatin resistance

Unknown

[119]

ITGB2-AS1

↑

Activating Wnt/β-catenin

-

Prognosis

Proliferation, apoptosis, migration, invasion

Unknown

[153]

LEF1-AS1

↑

Activating Wnt

HNRNPL/LEF1

-

Proliferation, migration, invasion

Transcriptional

[64]

LINC01128

↑

Activating Wnt/β-catenin

miR-299-3p/MMP2

-

Proliferation, migration, and invasion

Transcriptional

[75]

Lnc-MAP6-1:3

↑

Activating Wnt/β-catenin and Bax/Bcl-2

-

-

Proliferation, apoptosis

Post-transcriptional

[85]

LncSox4

↑

Activating β-catenin

-

-

Viability, migration

Post-transcriptional

[103]

LSINCT5

↑

Activating β-catenin

EZH2/APC

Prognosis

Proliferation, tumor growth

Transcriptional

[152]

MEG3

↓

Inhibit Wnt/β-catenin

miR-184/TCF4 and c-Myc

-

Cell viability, metastasis, apoptosis

Transcriptional

[187]

TMPO-AS1

↑

Activating Wnt/β-catenin

miR-199a-5p/WNT7B

-

Proliferation, apoptosis

Transcriptional

[86]

SNHG1

↑

Activating Wnt/β-catenin

miR-577/WNT2B

Tumor size, TNM stage, LNM

Proliferation, migration, EMT

Transcriptional

[146]

SNHG10

↑

Activating Wnt/β-catenin

miR-182-5p/FZD3

-

Proliferation, invasion

Transcriptional

[77]

TUG1

↑

Activating Wnt/β-catenin

miR-144-3p/EZH2

-

Proliferation, migration, invasion, apoptosis

Transcriptional

[108, 109]

UCA1

↑

Activating Wnt/β-catenin and NF-κB

miR-301a/CXCR4

-

Cell viability, migration, invasion, apoptosis

Transcriptional

[97, 188]

  1. AFAP1-AS1 actin filament-associated protein 1-antisense RNA 1, APC adenomatous polyposis coli, C2dat1 CAMK2D-associated transcript 1, CXCR4 C-X-C motif chemokine receptor 4, DLK1 delta-like homologue 1, DLX6-AS1 distal-less homeobox 6 antisense 1, DM distant metastasis, DSCAM-AS1 down syndrome cell adhesion molecule antisense RNA 1, EMT epithelial-mesenchymal transition, EZH2 enhancer of zeste homolog 2, FLVCR1-AS1 FLVCR1 antisense RNA 1, FZD3 Frizzled 3, TCF4 transcriptional factors T cell factor4, GHET1 Gastric carcinoma proliferation enhancing transcript 1, GSK-3β glycogen synthase kinase 3β, HNF1A-AS1 HNF1A-antisense 1, HNRNPL heterogeneous nuclear ribonucleoprotein L, HOTTIP HOXA transcript at the distal tip, ITGB2-AS1 ITGB2 antisense RNA1, LEF1 lymphoid enhance factor 1, LEF1-AS1 Lymphoid enhancer-binding factor 1 antisense RNA 1, LNM lymph node metastasis, LSINCT5 long stress-induced noncoding transcript 5, MEG3 maternally expressed gene 3, MMP2 maxtrix metalloproteinase 2, Sirt1 Sirtuin 1, SNHG1 small nucleolar RNA host gene 1, SNHG10 small nucleolar RNA host gene 10, TMPO-AS1 TMPO antisense RNA 1, TUG1 taurine upregulated gene 1, UCA1 urothelial carcinoma associated 1, USP47 ubiquitin-specific peptidase 47, ZEB1 zinc finger E-box-binding homeobox 1, ↑:upregulated, ↓:downregulated